Your assignment is to read the paper and write a report in which you:
This should be approximately 3-4 pages double-spaced (+ reference page)
1. Briefly review the major themes of the paper:
• What are “flipons”? What triggers them?
• What is ADAR? What functions do these proteins have in activation of immune responses? Increasing protein diversity?
• How is Z-DNA/ADAR important in development of cancer? (Would ADAR function as an oncogene or tumor suppressor?
• How is Z-DNA/ADAR important in cellular response to DNA damage?
• What genetic diseases are associated with Z-DNA/ADAR dysfunction?
• How is Z-DNA/ADAR important in cellular response to viral infection?
2. Choose one topic covered in the paper and do some research to elaborate some on the topic (e.g. Z-DNA flipon’s role in cancer; Z-DNA flipon’s role in Alzheimer’s;Z-DNA and immune response to viral infections..etc); You should include at least one references.
3. A paragraph or so in which you “think”, expand on what you have read, and propose possible therapeutics (or other applications) of your chosen topic (e.g use of Z-DNA inhibitors in treatment of cancer…etc.
(I need at least two sources) ( I upload the required paper , “Z-DNA the new biology”, and some other papers that are background informations)
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