Substance Use Disorder

Pharmacological Effects of Substances

As you delve further into information about the types of drugs used and abused, a broader understanding of SUDs can be gained by exploring the pharmacology of drugs. Each drug has a different (or varied) route of administration and each drug has its own prime effects and side effects. As a drug enters the body, it must have bioavailability to have the desired effect. Influencing the bioavailability of a drug depends on a number of factors, including the distribution of the drug and its biotransformation. Neurotransmission of a drug and factors such as neuroadaptation and the impact on neurotransmitters are factors of relevancy as one gains an understanding of how drugs affect the body (and how each drug user reacts to drugs in a unique way).

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This week, you will be given the opportunity to briefly explore pharmacological principles of the use and abuse of drugs. This will allow you to more firmly grasp the impact each drug of abuse might have on different systems of the body, including a drug’s occupation of neurotransmitter receptor sites and how such occupation leads to the “high” that one may experience when taking a drug.

Be sure to carefully review this week’s resources. You are expected to apply the information from these resources when you prepare this assignment. Assignment: Prepare a Lecture on Models of Substance Use Disorder

For this task, you will prepare a lecture suitable for a community college course on the pharmacological effects of a particular drug of abuse. This will be a PowerPoint or Emaze.

Be sure to include the following in your lecture:

Provide an opening statement regarding substance and the number of people affected by the substance, as well as statistics related to health and societal costs.

Present information on the drug’s pharmacology.

Discuss how the drug is typically administered, absorbed, and distributed throughout the body.

Include the concept of biotransformation, explain where it occurs, and then identify the pharmacological processes involved.

Explain the difference between effective dose and lethal dose and how these concepts relate to the therapeutic index of the drug you are presenting.

Discuss how this drug affects the process of neurotransmission and include in your discussion the impact this drug has on specific neurotransmitters.

Be sure to include information on tolerance (neuroadaptation) with this drug and the different types of tolerance experienced with this drug.

Length: 10-15 slides, including a slide for the resources; and a note section of 150-250 words.

Resources: In addition to information, find at least 3 research articles relevant to the pharmacology of the drug you are presenting (published within the past 5 years) to support your lecture.

Your lecture should demonstrate thoughtful consideration of the ideas and concepts with clip art pictures.

National Institute on Drug Abuse. (n.d.). NIDA InfoFacts: The Science of Drug Abuse and Addiction.

Physician Desk Reference. (2015). Homepage

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Concepts of Chemical Dependency

Doweiko, H. E. (2014). Concepts of chemical dependency (9th ed.). Bellevue, WA: Cengage Learning.

Chapter 3: A Brief Introduction to the Science of Pharmacology. For more information on Substance Use Disorder see this:

Substance Use Disorder

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